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Mark Macbeth

Assistant Professor - Chemistry Chemistry and Biochemistry - LAS
Mark Macbeth


Office: 361 Gallahue Hall, Lab: 380 Gallahue Hall

Education and Experience

B. S. Biological Sciences, University of Vermont

Ph. D. Biochemistry and Molecular Biology, The University of Chicago

Post-doctoral associate, Howard Hughes Medical Institute and Department of Biochemistry, University of Utah School of Medicine

Assistant Professor, Carnegie Mellon University


Teaching interests include bringing active learning methods and learning technologies to biochemistry and general chemistry classrooms. In recognition of these efforts I was named a teaching fellow of the National Academy of Sciences 2011-2012.  Courses taught:

  • The Natural World (general chemical science)
  • General Chemistry with laboratory
  • Biochemistry with laboratory
  • Advanced Biochemistry
  • Structural Methods

I'm currently developing the advanced course Chemical Mechanisms in Gene Expression and a structure/mechanism based Enzymology course.


Research interests include: 1)  the biochemical analysis of nucleic acid-protein interactions, including the structure and mechanism of RNA modifying enzymes, 2) substrate recognition and activity of microbial esterases, and 3) the role of metal ions in the chemical mechanism and allosteric regulation of enzymes. Research methods employed:

  • Kinetic analysis (including synthesis of inhibitors and mutants) of enzymatic activity
  • RNA, metal ion, and other ligand binding assays
  • X-ray crystallography of nucleic acids and proteins
  • Yeast genetics and molecular biology
  • Cell biology and cellular imaging