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Cumbay, Medhane

Assistant Professor - Pharmaceutics
College of Pharmacy/Health Science


Pharmacy Building - 361

Academic/Professional/Personal Focus

Areas of Expertise

  • General Pharmacology, Neuropharmacology, Molecular Biology, Biochemistry, Electrophysiology

Contributions: (published works or studies, conference presentations)

  1. Cumbay MG and Watts, VJ, G-alpha-q potentiation of adenylate cyclase type 9 activity through a Ca2+/calmodulin-dependent pathway. Biochemical Pharmacology. 69(8):1247-56 (2005).
  2. Cumbay MG and Watts, VJ, Novel regulatory properties of human type 9 adenylate cyclase. Journal of Pharmacology and Experimental Therapeutics. 310(1):108-15 (2004).
  3. Marona-Lewicka D, Kurrasch-Orbaugh D, Selken JR, Cumbay MG, Lisinicchia JG, Nichols DE; Reevalution of lisuride pharmacology: 5-hydroxytryptamine1A receptor-mediated behavioral effects overlap its other properties in rats. Journal of Psychopharmacology 164(1):93-107 (2002).
  4. Neve KA, Cumbay MG, Thompson KR, Yang R, Buck DC, Watts VJ, Durand CJ, Teeter MM; Modeling and mutational analysis of a putative sodium-binding pocket on the dopamine D2 receptor. Molecular Pharmacology 60 (2): 373-381(2001).
  5. Cumbay MG, Watts VJ; Heterologous sensitization of recombinant adenylate cyclases by activation of D2 dopamine receptors. Journal of Pharmacology and Experimental Therapeutics 297 (3): 1201-1209 (2001).
  6. Johnston CA, Cumbay MG, Vortherms TA, Watts VJ; Adrenergic agonists induce heterologous sensitization of adenylate cyclase in NS20Y-D2L cells. FEBS Letters 497 (2-3): 85-89 (2000).
  7. Blair JB, Kurrasch-Orbaugh D, Marona-Lewicka D, Cumbay MG, Watts VJ, Barker EL, Nichols DE; Effect of ring fluorination on the pharmacology of hallucinogenic tryptamines. Journal of Medicinal Chemistry 43 (24): 4701-4710 (2000).
  8. Schutzer WE, Watts VJ, Chapman J, Cumbay MG, Neve KA, Neve RL, Mader SL; Viral-mediated gene delivery of constitutively activated G alpha s alters vasoreactivity. Clinical and Experimental Pharmacology and Physiology 27 (1-2): 9-13 (2000).
  9. Eshleman AJ, Carmolli M, Cumbay M, Martens CR, Neve KA, Janowsky A; Characteristics of drug interactions with recombinant biogenic amine transporters expressed in the same cell type. Journal of Pharmacology and Experimental Therapeutics 289 (2): 877-885 (1999).
  10. Watts VJ, Wiens BL, Cumbay MG, Vu MN, Neve RL, Neve KA; Selective activation of G alpha(o) by D2L dopamine receptors in NS20Y neuroblastoma. Journal of Neuroscience 18 (21): 8692-8699 (1998).

Butler Assignment (classes or work duties)
Assistant Professor of Pharmacology



  • B.S. (Biochemistry/Biophysics) Oregon State University , 1995
  • Ph.D. (Molecular Pharmacology) Purdue University, 2004
  • Postdoctoral Fellow(Neuropharmacology/Neuroscience)
    Indiana University School of Medicine, 2004-2006

Association Memberships (professional/educational)

  • American Association for the Advancement of Science
  • American Society for Pharmacology and Experimental Therapeutics
  • Society for Neuroscience

Professional Experience

  • Instructor (Molecular Biology Workshop) Indiana University School of Medicine (2005)
  • Instructor (Biochemistry) Purdue University (2003-2004)
  • Graduate Teaching Assistant (Biochemistry) Purdue University (2002)
  • Research Associate ( Purdue University) 1998-2000
  • Research Associate ( Oregon Health Sciences University) 1995-1998
  • Reviewer for Journal of Pharmacology and Experimental Therapeutics
  • Reviewer for Neuroscience Letters