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Hoops, Geoffrey

Professor - Chemistry


Gallahue Hall - 335A

Academic/Professional/Personal Focus

Areas of Expertise
Biochemistry (Enzymology, Protein Spectroscopy)

Contributions: (published works or studies, conference presentations)

Publications in Refereed Journals:
(underlined authors are Butler University undergraduate students)


Gore, M.P.; Nanjappan, P.; Hoops, G.C.; Woodard, R.W.  “Synthesis of (E)- and (Z)-3-Deuteriophosphoenolpyruvate.”  Journal Of Organic Chemistry, 1990, 55: 758-760.


Liu, Y.-L.; Hoops, G.C.; Coward, J.K.  “A Comparison of Proteins and Peptides as Substrates for Microsomal and Solubilized Oligosaccharyltransferase.”  Bioorganic & Medicinal Chemistry Letters, 1994, 2(11): 1133-1141.


Hoops, G.C.; Townsend, L.B.; Garcia, G.A. “tRNA-Guanine Transglycosylase from Escherichia coli:  Structure-Activity Studies Investigating the Role of Aminomethyl Substituent of the Heterocyclic Substrate PreQ1.”  Biochemistry, 1995, 34 (46): 15381-15387.


Hoops, G.C.; Townsend, L.B.; and Garcia, G.A.  “Mechanism-Based Inactivation of tRNA-Guanine Transglycosylase (TGT) from Escherichia coli by 2-Amino-5-(fluoromethyl)pyrrolo[2,3-d]pyrimidin-4(3H)-one." Biochemistry, 1995 34 (47): 15539-15544.


Hoops, G.C.; Park, J.; Garcia, G.A. and Townsend, L.B.  “The Synthesis and Determination of Acidic Ionization Constants of Certain 5-Substituted 2-Aminopyrrolo[2,3-d]pyrimidine-4-ones and Methylated Analogs.” Journal of Heterocyclic Chemistry, 1996 33: 767-781.


Migawa, M.T., Hinkley, J.M., Hoops, G.C., and Townsend, L.B. "A Two Step Synthesis of the Nucleoside Q Precursor 2-Amino-5-cyano-7H-pyrrolo[2,3-d]pyrimidin-4-one (PreQ0)." Synthetic Communications, 1996 26(17): 3317-3322.

Cheng, C.S.; Hoops, G.C.; Earl, R.A. and Townsend, L.B. “Synthesis of Pyrrolo[2,3-d]pyrimidines that are Structurally Related to Methylated Guanosines from tRNA and the Nucleoside Q Analogs, PreQ0 and PreQ1Nucleosides and Nucleotides, 1997 16(4): 347-364.

Hoops, G.C., Zhang, P., Johnson, W.T., Paul, N., Bergstrom, D.E., and Davisson, V.J.  "Template Directed Incorporation of Nucleotide Mixtures Using Azole-Nucleobase Analogs" Nucleic Acids Research, 1997 25(24): 4866-4871.

Zhang, P., Johnson, W.T., Klewer, D., Paul, N., Hoops, G., Davisson, V.J., Bergstrom, D.E. “Exploratory studies on azole carboxamides as nucleobase analogs: thermal denaturation studies on oligodeoxyribonucleotide duplexes containing pyrrole-3-carboxamide”, Nucleic Acids Research, 1998 26(9): 2208-2215.

Paul, N., Nashine, V., Hoops, G., Zhang, P., Zhou, J., Bergstrom, D.E., and Davisson, V.J. "DNA polymerase template interactions probed by degenerate isosteric nucleobase analogs," Chemistry and Biology, 2003 10: 815-825.

Barrett, J.A.; Esteb, J.J.; Hoops, G.C.; Richter, J.M., “A solvent-free oxidation of 1-pentanol to pentanoic acid for the undergraduate organic laboratory”, Chem. Educator, 2004, 9: 1-2

Jared D. Persinger, Geoffrey C. Hoops, and Michael J. Samide; “Mass Spectrometry for the Masses”, Journal of Chemical Education, 2004, 81(8): 1169-1171.

Yo-Yuan Cheng, Huan-Cheng Chang, Geoffrey Hoops, and Meng-Chih Su; “Stabilization of yeast cytochrome c covalently immobilized on fused silica surfaces”, Journal of the American Chemical Society, 2004, 126: 10828-10829.

Casey M. Kraning, Tara L. Benz, Kayla S. Bloome, Gregory C. Campanello, Victoria S. Fahrenbach, Sheetal A. Mistry, Carrie Ann Hedge, Ken D. Clevenger, Keith M. Gligorich, Todd A. Hopkins, Geoffrey C. Hoops, Sergio B. Mendes, Huan-Cheng Chang and Meng-Chih Su; "Determination of Surface Coverage and Orientation of Reduced Cytochrome c on a Silica Surface with Polarized ATR Spectroscopy"
Journal of Physical Chemistry C, 2007, 111, 13062-13067.

Rodrigo S. Wiederkehr, Geoffrey C. Hoops, Mustafa M. Aslan, Courtney L. Byard, and Sergio B. Mendes; "Investigations on the Q and CT Bands of Cytochrome c Submonolayer Adsorbed on an Alumina Surface Using Broadband Spectroscopy with Single-Mode Integrated Optical Waveguides"; Journal of Physical Chemistry C, 2009, 113, 8306-8312.

Rodrigo S. Wiederkehr, Geoffrey C. Hoops, and Sergio B. Mendes; "Effects of sodium chloride on the properties of chlorophyll a sub-monolayer adsorbed onto hydrophobic and hydrophilic surfaces using broadband spectroscopy with single-mode integrated optical waveguides"; Optical Engineering, 2011, 50, doi:10.1117/1.3564421

R. Jeremy Johnson, Christopher J. Savas, Zachary Kartje, Geoffrey C. Hoops; "Rapid and Adaptable Measurement of Protein Thermal Stability By Differential Scanning Fluorimetry: Updating a Common Biochemical Laboratory Experiment"; Journal of Chemical Education, 2014, 91 1077-1080

Lukowski, Jessica K.; Savas, Christopher P.; Gehring, Alexandra M.; McKary, Magy G.; Adkins, Chinessa T.; Lavis, Luke D.; Hoops, Geoffrey C.; Johnson, R. Jeremy; "Distinct substrate selectivity of a metabolic hydrolase from Mycobacterium tuberculosis"
Biochemistry, 2014, 53, 7386-7395.

R. Jeremy Johnson, Geoffrey C. Hoops, Christopher J. Savas, Zachary Kartje, and Luke D. Lavis; "A Sensitive and Robust Enzyme Kinetic Experiment using Microplates and Fluorogenic Ester Substrates"; Journal of Chemical Education, 2015, in press DOI 10.1021/ed500452f


(underlined authors are Butler University undergraduate students)

·       National Meeting of the American Society for Biochemistry and Molecular Biology (ASBMB), San Diego, CA, April 26-30, 2014

o   Geoffrey C. Hoops, Christopher Savas, R. Jeremy Johnson “Probing the active site of the Rv0045c esterase from Mycobacterium tuberculosis

o   Lindsey Drake and Geoffrey C. Hoops “Thermal denaturation of Mycobacterium tuberculosis protein Rv0045c monitored by intrinsic tryptophan fluorescence”

o   Jessica K. Lukowski, Geoffrey C. Hoops, Magy McKary, R. Jeremy Johnson “Active site mutants of Rv0045c esterase from Mycobacterium tuberculosis

·       National Meeting of the American Society for Biochemistry and Molecular Biology (ASBMB), Boston, MA, April 20-24, 2013

o   Geoffrey C. Hoops, Christopher Savas, R. Jeremy Johnson “Divalent metal ion effect upon Rv0045c esterase enzymatic activity”

o   Christopher Savas, Geoffrey C. Hoops and R. Jeremy Johnson“Substrate specificity of Rv0045c, a bacterial esterase from Mycobacterium tuberculosis

Butler Assignment (classes or work duties)

Biochemistry (CH361, CH462, CH463)

General Chemistry (CH105, CH106)

Organic Chemistry (CH351)



B.A. , Chemistry, Grinnell College, Grinnell, IA, 1989

Ph.D., Medicinal Chemistry, University of Michigan, Ann Arbor, MI, 1995

Professional Experience

Postdoctoral Research Fellow, Purdue University, 1995-1999

Assistant Professor of Chemistry, Butler University, 1999-2006

Associate Professor of Chemistry, Butler University, 2006-2013

Professor of Chemistry, Butler University, 2013-present