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Hoops, Geoffrey

Professor - Chemistry
Chemistry

ghoops@butler.edu
317/940-9147

Gallahue Hall - 335A




Academic/Professional/Personal Focus

Areas of Expertise
Spectroscopy of Proteins Adsorbed to Surfaces

Contributions: (published works or studies, conference presentations)

Publications in Refereed Journals:
(underlined authors are Butler University undergraduate students)

 

Gore, M.P.; Nanjappan, P.; Hoops, G.C.; Woodard, R.W.  “Synthesis of (E)- and (Z)-3-Deuteriophosphoenolpyruvate.”  Journal Of Organic Chemistry, 1990, 55: 758-760.

 

Liu, Y.-L.; Hoops, G.C.; Coward, J.K.  “A Comparison of Proteins and Peptides as Substrates for Microsomal and Solubilized Oligosaccharyltransferase.”  Bioorganic & Medicinal Chemistry Letters, 1994, 2(11): 1133-1141.

 

Hoops, G.C.; Townsend, L.B.; Garcia, G.A. “tRNA-Guanine Transglycosylase from Escherichia coli:  Structure-Activity Studies Investigating the Role of Aminomethyl Substituent of the Heterocyclic Substrate PreQ1.”  Biochemistry, 1995, 34 (46): 15381-15387.

 

Hoops, G.C.; Townsend, L.B.; and Garcia, G.A.  “Mechanism-Based Inactivation of tRNA-Guanine Transglycosylase (TGT) from Escherichia coli by 2-Amino-5-(fluoromethyl)pyrrolo[2,3-d]pyrimidin-4(3H)-one." Biochemistry, 1995 34 (47): 15539-15544.

 

Hoops, G.C.; Park, J.; Garcia, G.A. and Townsend, L.B.  “The Synthesis and Determination of Acidic Ionization Constants of Certain 5-Substituted 2-Aminopyrrolo[2,3-d]pyrimidine-4-ones and Methylated Analogs.” Journal of Heterocyclic Chemistry, 1996 33: 767-781.

 

Migawa, M.T., Hinkley, J.M., Hoops, G.C., and Townsend, L.B. "A Two Step Synthesis of the Nucleoside Q Precursor 2-Amino-5-cyano-7H-pyrrolo[2,3-d]pyrimidin-4-one (PreQ0)." Synthetic Communications, 1996 26(17): 3317-3322.

 

Cheng, C.S.; Hoops, G.C.; Earl, R.A. and Townsend, L.B. “Synthesis of Pyrrolo[2,3-d]pyrimidines that are Structurally Related to Methylated Guanosines from tRNA and the Nucleoside Q Analogs, PreQ0 and PreQ1Nucleosides and Nucleotides, 1997 16(4): 347-364.

Hoops, G.C., Zhang, P., Johnson, W.T., Paul, N., Bergstrom, D.E., and Davisson, V.J.  "Template Directed Incorporation of Nucleotide Mixtures Using Azole-Nucleobase Analogs" Nucleic Acids Research, 1997 25(24): 4866-4871.

Zhang, P., Johnson, W.T., Klewer, D., Paul, N., Hoops, G., Davisson, V.J., Bergstrom, D.E. “Exploratory studies on azole carboxamides as nucleobase analogs: thermal denaturation studies onoligodeoxyribonucleotide duplexes containing pyrrole-3-carboxamide”, Nucleic Acids Research, 1998 26(9): 2208-2215.

Paul, N., Nashine, V., Hoops, G., Zhang, P., Zhou, J., Bergstrom, D.E., and Davisson, V.J. "DNA polymerase template interactions probed by degenerate isosteric nucleobase analogs," Chemistry and Biology, 2003 10: 815-825.

Barrett, J.A.; Esteb, J.J.; Hoops, G.C.; Richter, J.M., “A solvent-free oxidation of 1-pentanol to pentanoic acid for the undergraduate organic laboratory”, Chem. Educator, 2004, 9: 1-2

Jared D. Persinger, Geoffrey C. Hoops, and Michael J. Samide; “Mass Spectrometry for the Masses”, J. Chem. Ed., 2004, 81(8): 1169-1171.

Yo-Yuan Cheng, Huan-Cheng Chang, Geoffrey Hoops, and Meng-Chih Su; “Stabilization of yeast cytchrome c covalently immobilized on fused silica surfaces”, J. Am. Chem. Soc., 2004, 126: 10828-10829.

Casey M. Kraning, Tara L. Benz, Kayla S. Bloome, Gregory C. Campanello, Victoria S. Fahrenbach, Sheetal A. Mistry, Carrie Ann Hedge, Ken D. Clevenger, Keith M. Gligorich, Todd A. Hopkins, Geoffrey C. Hoops, Sergio B. Mendes, Huan-Cheng Changb and Meng-Chih Su; "Determination of Surface Coverage and Orientation of Reduced Cytochrome c on a Silica Surface with Polarized ATR Spectroscopy"
J. Phys. Chem. C, 2007, 111, 13062-13067.

Rodrigo S. Wiederkehr, Geoffrey C. Hoops, Mustafa M. Aslan, Courtney L. Byard, and Sergio B. Mendes; "Investigations on the Q and CT Bands of Cytochrome c Submonolayer Adsorbed on an Alumina Surface Using Broadband Spectroscopy with Single-Mode Integrated Optical Waveguides"; J. Phys. Chem. C, 2009, 113, 8306-8312.

Rodrigo S. Wiederkehr, Geoffrey C. Hoops, and Sergio B. Mendes; "Effects of sodium chloride on the properties of chlorophyll a sub-monolayer adsorbed onto hydrophobic and hydrophilic surfaces using broadband spectroscopy with single-mode integrated optical waveguides"; Opt. Engin, 50, 071109 (Apr 21, 2011); doi:10.1117/1.3564421

 

Recent PRESENTATIONS AT PROFESSIONAL CONFERENCES:
(underlined authors are Butler University undergraduate students)

·       SPIE Optics and Electronics, Prague, Czech Rebublic, April 18-21 2011

o   Rodrigo S. Wiederkehr, Univ. of Louisville (United States); Geoffrey C. Hoops, Butler Univ. (United States); Sergio B. Mendes, Univ. of Louisville (United States), “Single-mode integrated optical waveguides for spectroscopy of molecular sub-monolayers”

·       126th Annual Meeting of the Indiana Academy of Science, Indianapolis, IN, March 5, 2011

o   Geoffrey C. Hoops, Katherine Schmid, Ted Seger: “Progress Toward Construction of a Plasmid Library of the Anthocyanidin Synthase (ANS) Gene from Onions (Allium cepa)”

·       2010 International Chemical Congress of Pacific Basin Societies (a.k.a. Pacifichem). Honolulu, Hawaii, December 15-20, 2010

o   Geoffrey Hoops and Brianna Richine: “Cytochrome c adsorption to chemically modified silica surfaces”

·       2009 Optical MEMS and Nanophotonics, Clearwater Beach, FL August 17-20 2009

o   Rodrigo Wiederkehr, Geoffrey Hoops, Mustafa Aslan, Courtney Byard and Sergio Mendes: “Spectroscopic Studies in Protein Films with Highly Sensitive Single-Mode Guided-Wave Platforms”

·       Plant Biology 2009; Honolulu, Hawaii July 18-22, 2009

o   Schmid, Katherine M., Hoops, Geoffrey C.: “Spectral quality and template suitability of onion DNA prepared by the spindling technique”

·       234th National Meeting of the American Chemical Society, Boston, MA, August, 2007

o   Ken D. Clevenger, Geoffrey Hoops, Todd A. Hopkins, Kayla S. Bloome, Casey M. Kraning, Meng-Chih Su, Marcelo B. Pereira, Sergio B. Mendes:
Probing of electrostatically adsorbed cytochrome c by attenuated total internal reflection spectroscopy on a fused silica surface

o   Todd A. Hopkins, Kayla S. Bloome, Carrie Ann Hedge, Casey M. Kraning, Meng-Chih Su, and Geoffrey C. Hoops: "Spectroscopic studies of cytochrome c adsorbed to silica"

·       233rd National Meeting of the American Chemical Society, Chicago, IL, March, 2007

o   Carrie Ann Hedge, Todd A. Hopkins, Geoffrey C. Hoops and Meng-Chih Su: "Adsorption studies of cytochrome c to a silica nanoparticle surface"

·       232nd National Meeting of the American Chemical Society, San Francisco, CA, September 10-14, 2006

o   Casey M. Kraning, Kayla S. Bloome, Carrie Ann Hedge, Ken D. Clevenger, Tara L. Benz, Todd A. Hopkins, Geoffrey C. Hoops and Meng-Chih Su: "Comparison of surface adsorption between reduced and oxidized cytochrome c on fused silica"

o   Kayla S. Bloome, Casey M. Kraning, Carrie Ann Hedge, Ken D. Clevenger, Tara L. Benz, Todd A. Hopkins, Geoffrey C. Hoops and Meng-Chih Su: "ISE upon surface adsorption of Cytochrome c to a fused silica surface"

·       231st  National Meeting of the American Chemical Society, Atlanta, GA, March 26-30, 2006

o   Victoria S. Fahrenbach, Tara L. Benz, Gregory C. Campanello, Sheetal Mistry, Geoffrey C. Hoops, Todd A. Hopkins, and Meng-Chih Su: "Ionic strength effect of Cytochrome c folding/unfolding on a fused silica surface"

o   Tara L. Benz, Gregory C. Campanello, Victoria S. Fahrenbach, Sheetal A. Mistry, Carrie Ann Hedge, Ken D. Clevenger, Meng-Chih Su, Geoffrey C. Hoops: "Attenuated total internal reflection study of reduced and oxidized cytochrome c adsorbed on a fused silica surface"

·       2005 International Chemical Congress of Pacific Basin Societies. Honolulu, Hawaii, December 15-22, 2005

o   Hoops, Geoffrey C.; Fahrenbach, Victoria S.; Mistry, Sheetal; Su, Meng-Chih; Hopkins, Todd A.;
Cheng, Yo-Yuan; Chang, and Huan-Cheng; "Conformational Effects of Differential Attachment Modes of Cytochrome c to a Fused Silica Surface"

o   Todd A. Hopkins, Sheetal Mistry, Scott A. Hocker, Tara L. Benz, Victoria S. Fahrenbach, Keith M. Gligorich, Geoffrey C. Hoops, Meng-Chih Su and Huan-Cheng Chang; "Surface Coverage Dependent Properties of Cytochrome c Adsorbed to a Fused Silica Surface"

o   Meng-Chih Su, Tara L. Benz, Gregory C. Campanello, Victoria S. Fahrenbach,  Sheetal Mistry, Geoffrey C. Hoops, Todd A. Hopkins and Huan-Cheng Chang; "Characterization of reduced cytochrome c adsorption on fused silica surface"

·       228th National Meeting of the American Chemical Society, Philadelphia, PA, August 22-26, 2004

o   Tara Benz, Keith M. Gligorich, Scott A. Hocker, Sheetal Mistry, Victoria Fahrenbach, Gregory C. Campanello, Meng-Chih Su, Geoffrey Hoops, and Todd A. Hopkins: “Attenuated total internal reflection study of the conformational changes of reduced cytochrome c on a fused silica surface”

o   Sheetal Mistry, Victoria Fahrenbach, Gregory C. Campanello, Tara Benz, Keith M. Gligorich, Scott A. Hocker, Geoffrey Hoops, Todd A. Hopkins and Meng-Chih Su: “Attenuated total internal reflection study of the conformational changes of oxidized cytochrome c on a fused silica surface”

o   Gregory C. Campanello, Victoria Fahrenbach, Tara Benz, Sheetal Mistry, Keith M. Gligorich, Scott A. Hocker, Todd A. Hopkins, Geoffrey C. Hoops,  and Meng-Chih Su: “Surface spectroscopy of the KatP catalase-peroxidase”

o   Victoria Fahrenbach, Gregory C. Campanello, Tara Benz, Sheetal Mistry, Todd A. Hopkins, Meng-Chih Su, Scott A. Hocker, Keith M. Gligorich, and Geoffrey C. Hoops: “Ionic strength effect of cytochrome c folding/unfolding on a fused silica surface”

·       36th Annual Central Regional Meeting of the American Chemical Society, June 2-4, 2004, IUPUI,  Indianapolis, IN

o   Sheetal Mistry, Tara Benz, Scott Hocker, Keith Gligorich, Victoria Fahrenbach, Gregory Campanello, Geoffrey Hoops, Meng-Chih Su, and Todd Hopkins: “Attenuated Total Internal Reflection Study of the Conformational Changes of Oxidized Cytochrome c on a Fused Silica Surface”

o   Victoria Fahrenbach, Gregory Campanello, Sheetal Mistry, Tara Benz, Scott Hocker, Keith Gligorich, Geoffrey Hoops, Meng-Chih Su, and Todd Hopkins: “The Effect of Ionic Strength Upon Cytochrome C Folding/Unfolding While Adsorbed to a Fused Silica Surface.”

·       National Meeting of the American Chemical Society, Anaheim, CA, March 28 – April 1 2004

o   Meng Chih Su, Huan-Cheng Chang, Keith M. Gligorich, Geoffrey C. Hoops, Todd A. Hopkins, Scott A. Hocker, Shen-Hsien Lin, Sheetal Mistry, and Yo-Yuan Cheng: “Alcohol-induced conformational changes of Cytochrome c on fused silica surfaces”

 

Butler Assignment (classes or work duties)

Biochemistry (CH361, CH462, CH463)

General Chemistry (CH105, CH106)

Organic Chemistry (CH351)


Education/Experience

Education/Degrees

B.A. , Chemistry, Grinnell College, Grinnell, IA, 1989

Ph.D., Medicinal Chemistry, University of Michigan, Ann Arbor, MI, 1995

Professional Experience

Postdoctoral Research Fellow, Purdue University, 1995-1999

Assistant Professor of Chemistry, Butler University, 1999-2006

Associate Professor of Chemistry, Butler University, 2006-2013

Professor of Chemistry, Butler University, 2013-present